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KMID : 0371320070730050406
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Journal of the Korean Surgical Society
2007 Volume.73 No. 5 p.406 ~ p.411
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The Significance of the Lymphatic Micro Vessel Density and Vascular Endothelial Growth Factor- C Expression for Colorectal Cancer
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Kim Tae-Hee
Kim Yong-Seok
Choi Young-Cheol
Kim Beom-Gyu
Lee Tae-Jin
Park Yong-Gum
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Abstract
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Purpose: Studying the prognostic factors of distant metastasis is quite important for predicting these patients’ prognosis and also for providing standards for post-operative adjuvant chemotherapy. Microbiological studies currently enable researchers to look for new predictors of distant metastasis in patients with colon cancers. In this study, the VEGF-C expression and stain rate of D2-40 were investigated as prognostic factors.
Methods: 79 Specimens were collected from the patients who underwent colorectal operation and they were pathologicaly diagnosed with cancer at Chung-Ang University hospital from March, 2003 to Sept. 2005. The specimens were immunohistochemically stained to detect the VEGF-c expression and the D2- 40 stain rate.
Results: The VEGF-C expression was related to lymph node metastasis, tumor embolism and the frequency of the T- stage, but it was not related to progression of cancer. The D2-40 stained lymphatic density was significantly increased in the cases with lymph node metastasis and in the tumor embolism cases; furthermore, the density became higher in relation to the increased T-stage and progression of cancer.
Conclusion: The VEGF-C expression and lymphatic vessel density appear to be prognostic factors for colon cancer. (J Korean Surg Soc 2007;73:406-411)
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KEYWORD
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Colorectral cancer, VEGF-C, D2-40, Lymphatic microvessel density
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